Description

1-(5-o-Methoxytrityl-2-Deoxy--D-Xylofuranosyl)Uracil is a sophisticated nucleoside derivative, specifically a protected uracil-xylofuranosyl conjugate, designed for advanced oligonucleotide synthesis and medicinal chemistry research. This compound is a critical building block for the development of modified nucleic acid analogs, enabling precise control over structure and function. It is essential for researchers and manufacturers in the fields of antisense oligonucleotide (ASO) development, prodrug synthesis, and carbohydrate chemistry, where high-purity, specialty intermediates are required.

Application

• Oligonucleotide Synthesis: A key protected intermediate for the solid-phase or solution-phase synthesis of modified DNA/RNA strands containing xylofuranosyl-uracil moieties.
• Antisense & siRNA Therapeutics: Used in the research and development of novel therapeutic oligonucleotides targeting genetic diseases.
• Prodrug Development: Serves as a precursor for creating nucleoside prodrugs with enhanced bioavailability and targeted delivery.
• Medicinal Chemistry & Drug Discovery: A valuable scaffold for structure-activity relationship (SAR) studies in the search for new antiviral or anticancer agents.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and function.
• Carbohydrate Chemistry: Used in the synthesis of complex nucleoside-carbohydrate hybrids and glycoconjugates.

Basic Information

Product Name	1-(5-o-Methoxytrityl-2-Deoxy--D-Xylofuranosyl)Uracil
CAS No.	2072145-82-3
Molecular Formula	C30H28N2O7
Molecular Weight	528.55 g/mol
Synonyms	5'-O-Methoxytrityl-2'-deoxy--D-xylofuranosyluracil; 1-(5-O-Monomethoxytrityl-2-deoxy--D-xylofuranosyl)uracil; MMTr-dXylof-U; 2'-Deoxy--D-xylofuranosyluracil 5'-O-MMTr ether; 1-[5-O-(4-Methoxyphenyl)diphenylmethyl-2-deoxy--D-xylofuranosyl]uracil; Protected Xylofuranosyl Uracil; Uracil, 1-[5-O-[(4-methoxyphenyl)diphenylmethyl]-2-deoxy--D-xylofuranosyl]-
EINECS	Contact for details

Quality Control

Our production of 1-(5-o-Methoxytrityl-2-Deoxy--D-Xylofuranosyl)Uracil adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing comprehensive analytical results, including HPLC purity, NMR confirmation, and moisture content, are provided with every shipment. We support compliance with cGMP standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.