Description

3'-o-Methyl-2'-o-Acetyl-5'-o-Benzoyluridine is a specifically protected nucleoside derivative, a crucial building block in synthetic organic chemistry. This compound matters because it provides precise control over functional group reactivity, enabling the synthesis of complex oligonucleotides and modified RNA molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in nucleic acid chemistry, antisense drug development, and oligonucleotide synthesis.

Application

• Oligonucleotide Synthesis: A key protected intermediate in the solid-phase and solution-phase synthesis of modified RNA and DNA strands.
• Antisense & siRNA Research: Used to create nucleoside phosphoramidites for the development of therapeutic oligonucleotides targeting specific genes.
• Medicinal Chemistry: Serves as a precursor for novel nucleoside analogs with potential antiviral or anticancer activity.
• Bioconjugation: Facilitates the site-specific labeling of oligonucleotides with probes, dyes, or other functional molecules.
• Chemical Biology Tools: Enables the study of RNA structure, function, and protein-RNA interactions through incorporation into synthetic oligonucleotides.

Basic Information

Item	Detail
Product Name	3'-o-Methyl-2'-o-Acetyl-5'-o-Benzoyluridine
CAS No.	2072145-71-0
Molecular Formula	C19H20N2O8
Molecular Weight	404.37 g/mol
Synonyms	2'-O-Acetyl-3'-O-methyl-5'-O-benzoyluridine; 3'-O-Methyl-2'-O-acetyl-5'-O-benzoyluridine; 1-[(2R,3R,4R,5R)-3-Acetyloxy-4-methoxy-5-(phenylcarbonyloxy)oxolan-2-yl]pyrimidine-2,4-dione; 2',3'-Di-O-protected Uridine Derivative; Protected Uridine Monomer; Uridine, 2'-acetate 3'-methyl ether 5'-benzoate
EINECS	Contact for details

Quality Control

Our 3'-o-Methyl-2'-o-Acetyl-5'-o-Benzoyluridine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.