Description

5'-O-(4,4'-Dimethoxytrityl)-3'-O-Levulinyl-2'-Deoxyadenosine is a highly functionalized, protected nucleoside derivative essential for oligonucleotide synthesis. This compound serves as a critical building block in the solid-phase synthesis of DNA and RNA sequences, enabling precise control over genetic material assembly. It is primarily required by pharmaceutical R&D teams, biotechnology companies, and academic research institutions engaged in the development of antisense oligonucleotides, siRNA, aptamers, and diagnostic probes.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key phosphoramidite precursor for the automated synthesis of DNA strands.
• Antisense Oligonucleotide (ASO) Development: Used in the research and production of therapeutic ASOs targeting genetic diseases.
• siRNA and miRNA Synthesis: Critical for constructing short interfering RNA and microRNA sequences for gene silencing applications.
• Diagnostic Probe Manufacture: Enables the production of labeled DNA probes for PCR, sequencing, and microarray technologies.
• Aptamer Research: Employed in the synthesis of DNA aptamers for therapeutic and sensor applications.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile intermediate for modifying nucleic acids and exploring structure-activity relationships.

Basic Information

Product Name	5'-O-(4,4'-Dimethoxytrityl)-3'-O-Levulinyl-2'-Deoxyadenosine
CAS No.	2072145-67-4
Molecular Formula	C38H39N5O8
Molecular Weight	693.75 g/mol
Synonyms	5'-O-DMT-3'-O-Lev-2'-dA; DMT-dA(Lev); 2'-Deoxyadenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-(4-oxopentanoyl)-; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-O-levulinate (common protected form); 5'-DMT-3'-Lev-2'-deoxyadenosine; DMT-dA-Lev; Protected 2'-Deoxyadenosine Derivative; DNA Synthesis Building Block
EINECS	Contact for details

Quality Control

Our 5'-O-(4,4'-Dimethoxytrityl)-3'-O-Levulinyl-2'-Deoxyadenosine is manufactured under strict quality systems to ensure it meets the exacting standards required for oligonucleotide synthesis. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. Certificates of Analysis (COA) with detailed specifications are provided to guarantee lot-to-lot consistency and suitability for sensitive pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.