Description

2'-o-Acetyl-5'-o-(p-Toluoyl)-3'-Deoxy-3'-Fluoro-3-Deazauridine is a sophisticated nucleoside analog intermediate, specifically designed for advanced pharmaceutical research and development. This compound is critical for medicinal chemists working on novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases and cellular replication pathways. Its precise chemical modifications make it an essential building block for synthesizing next-generation modified nucleosides with enhanced metabolic stability and targeted activity. Researchers in drug discovery and process development rely on this high-purity intermediate to accelerate their synthetic routes and ensure reproducible results.

Application

• Pharmaceutical Intermediate: A key protected precursor in the multi-step synthesis of novel 3'-deoxy-3'-fluoro-3-deazauridine analogs for antiviral and anticancer drug candidates.
• Antiviral Pro-drug Development: Used in research to develop pro-drug forms of nucleoside analogs, aiming to improve bioavailability and targeted delivery.
• Medicinal Chemistry Research: Serves as a critical scaffold for structure-activity relationship (SAR) studies to optimize potency and reduce off-target effects in nucleoside-based therapies.
• Process Chemistry & Scale-up: Employed in the development and optimization of robust, scalable synthetic routes for active pharmaceutical ingredients (APIs) under cGMP conditions.
• Biochemical Tool Compound: Utilized in enzymatic studies to investigate the mechanisms of viral polymerases and cellular nucleic acid metabolism.
• Labeled Compound Synthesis: Acts as a starting material for the synthesis of isotopically labeled (e.g., 13C, 15N, 2H) nucleosides for metabolic and pharmacokinetic studies.

Basic Information

Product Name	2'-o-Acetyl-5'-o-(p-Toluoyl)-3'-Deoxy-3'-Fluoro-3-Deazauridine
CAS No.	2072145-56-1
Molecular Formula	C23H24FN3O7
Molecular Weight	473.45 g/mol
Synonyms	3-Deaza-3'-fluoro-2'-O-acetyl-5'-O-(4-methylbenzoyl)uridine; 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-((4-methylbenzoyl)oxy)tetrahydrofuran-2-yl)-4-((4-methylbenzoyl)oxy)pyrimidin-2(1H)-one (acetylated derivative); 3'-Deoxy-3'-fluoro-3-deazauridine 2',5'-di-O-acyl protected intermediate; 2'-O-Acetyl-5'-O-p-toluoyl-3'-deoxy-3'-fluoro-3-deazauridine; 3'-Fluoro-3-deazauridine protected intermediate; p-Toluoyl/ Acetyl protected 3'-fluoro-3-deazauridine; FC-3DAU protected intermediate
EINECS	Contact for details

Quality Control

Our production of 2'-o-Acetyl-5'-o-(p-Toluoyl)-3'-Deoxy-3'-Fluoro-3-Deazauridine adheres to stringent quality protocols suitable for pharmaceutical R&D applications. Each batch is characterized and released based on comprehensive analytical data, including HPLC for purity, NMR for structural confirmation, and MS for identity. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability, batch-to-batch consistency, and compliance with your research specifications. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere or with desiccant for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Assay	95.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.