Description

N2-Isobutyryl-O6-(4-Pivaloyloxybenzyl)-7'-Oh-n-Trityl-Morpholino Guanosine is a sophisticated, protected nucleoside phosphoramidite precursor, a critical building block in the automated synthesis of oligonucleotides. Its value lies in enabling the precise and efficient construction of complex nucleic acid sequences, particularly for research and therapeutic applications. This high-purity intermediate is essential for pharmaceutical R&D, biotechnology companies, and academic laboratories focused on antisense oligonucleotides, siRNA, and other advanced genetic medicines. The compound, CAS 2072145-52-7, is designed for demanding synthetic workflows where reliability and consistency are paramount.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated synthesis of morpholino-based oligonucleotides.
• Antisense Therapeutic Development: For the research and production of antisense oligonucleotides (ASOs) targeting specific genes for therapeutic intervention.
• siRNA and miRNA Synthesis: Used in the construction of short interfering RNA (siRNA) and microRNA (miRNA) analogs for gene silencing studies.
• Diagnostic Probe Manufacture: Enables the creation of high-specificity labeled probes for diagnostic assays and genomic research.
• Synthetic Biology: A vital reagent for constructing novel synthetic nucleic acids and genetic circuits.
• Academic and Pharmaceutical R&D: Supports fundamental research in nucleic acid chemistry and the development of novel genetic medicines.

Basic Information

Product Name	N2-Isobutyryl-O6-(4-Pivaloyloxybenzyl)-7'-Oh-n-Trityl-Morpholino Guanosine
CAS No.	2072145-52-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	7'-Hydroxy-N2-isobutyryl-O6-[4-[(2,2-dimethylpropanoyl)oxy]benzyl]-N-tritylmorpholino-guanosine; N2-Ibu-O6-PivOMe-bzI-7'-OH-G(morpholino)Tr-CE Phosphoramidite precursor; Guanosine, N2-(2-methyl-1-oxopropyl)-O6-[4-[(2,2-dimethyl-1-oxopropoxy)methyl]phenyl]methyl]-7'-hydroxy-N-tritylmorpholino-; Protected Morpholino Guanosine Monomer; MOE-G (Tr) Phosphoramidite Synthon
EINECS	Not listed

Quality Control

This high-value synthetic intermediate is produced under strict quality-controlled conditions to ensure batch-to-batch consistency essential for oligonucleotide synthesis. Quality is verified through advanced analytical techniques including HPLC, NMR, and mass spectrometry. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.