Description

2'-Deoxy-2'-Fluoro-N3-(n-Dodecyl)-β-D-Arabinouridine is a chemically modified nucleoside analog, specifically engineered with a long-chain alkyl substituent at the N3 position. This modification is critical for enhancing the compound's lipophilicity and membrane permeability, making it a valuable intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies focused on developing novel antiviral and anticancer therapeutics, particularly in the field of oligonucleotide and prodrug synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Oligonucleotide Chemistry: Used in the research and development of modified antisense oligonucleotides (ASOs) and siRNA constructs to enhance stability and cellular uptake.
• Biochemical Research: Serves as a critical tool for studying enzyme mechanisms, particularly those involving nucleoside kinases and polymerases.
• Prodrug Development: The n-dodecyl chain facilitates the creation of lipophilic prodrugs aimed at improving oral bioavailability and targeted delivery.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in regulatory and R&D settings.

Basic Information

Item	Detail
Product Name	2'-Deoxy-2'-Fluoro-N3-(n-Dodecyl)-β-D-Arabinouridine
CAS No.	2072145-43-6
Molecular Formula	C21H35FN2O5
Molecular Weight	414.52 g/mol
Synonyms	N3-Dodecyl-2'-fluoro-2'-deoxy-β-D-arabinouridine; 2'-F-araU-C12; 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-dodecylpyrimidine-2,4(1H,3H)-dione; 2'-Deoxy-2'-fluoro-N3-dodecyl-β-D-arabinofuranosyluracil; N3-Dodecyl-2'-F-2'-deoxyarabinouridine; β-D-Arabinouridine, 2'-deoxy-2'-fluoro-N3-dodecyl-
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Fluoro-N3-(n-Dodecyl)-β-D-Arabinouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) documenting full specifications are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.