Description

3'-β-Azido-2',3'-Dideoxy-5'-o-(4-Methoxytrityl)Uridine is a key nucleoside analog intermediate, specifically designed for advanced pharmaceutical research and synthesis. This compound is critical for the development of antiviral and anticancer therapeutics, particularly in the synthesis of modified oligonucleotides and prodrugs. It is essential for R&D scientists and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity building blocks for nucleoside-based drug discovery programs.

Application

• Antiviral Drug Intermediate: A crucial precursor in the synthesis of dideoxynucleoside analogs used to target viral polymerases.
• Anticancer Prodrug Development: Serves as a building block for creating nucleoside-based chemotherapeutic agents.
• Oligonucleotide Synthesis: Used in the preparation of modified DNA/RNA strands for antisense and siRNA therapeutic applications.
• Biochemical Research: Employed as a specialized reagent in enzymatic studies and metabolic pathway investigations.
• Pharmaceutical R&D: A vital starting material for medicinal chemistry programs focused on nucleoside modifications.
• Labeled Compound Synthesis: Acts as an intermediate for introducing azido functional groups for click chemistry and bioconjugation.

Basic Information

Product Name	3'-β-Azido-2',3'-Dideoxy-5'-o-(4-Methoxytrityl)Uridine
CAS No.	2072145-36-7
Molecular Formula	C30H27N5O6
Molecular Weight	553.57 g/mol
Synonyms	5'-O-(4-Methoxytrityl)-3'-azido-2',3'-dideoxyuridine; 3'-Azido-3'-deoxy-5'-O-(4-methoxytrityl)uridine; MMTr-AzddU; 3'-N3-5'-MMTr-dU; 2',3'-Dideoxy-3'-azido-5'-O-(4-methoxytrityl)uridine; 5'-O-MMTr-3'-azido-2',3'-ddU; AZT-MMTr Intermediate; Uridine, 2',3'-dideoxy-3'-azido-5'-O-[4-methoxyphenyl(diphenyl)methyl]-
EINECS	Contact for details

Quality Control

Every batch of 3'-β-Azido-2',3'-Dideoxy-5'-o-(4-Methoxytrityl)Uridine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We adhere to stringent in-house specifications suitable for research and pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing HPLC purity, NMR confirmation, and other critical parameters is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light). For long-term storage, consider keeping the material under inert atmosphere (e.g., argon or nitrogen) in a freezer (-20°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.