Description

3'-Azido-3'-Deoxy-5'-Iodouridine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a versatile building block for creating novel antiviral and anticancer agents. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in nucleoside chemistry, medicinal chemistry, and the development of targeted therapeutics.

Application

• Medicinal Chemistry Research: A key intermediate in the synthesis of novel nucleoside analogs with potential antiviral or anticancer activity.
• Antiviral Drug Development: Used as a building block for probing structure-activity relationships (SAR) in the search for new inhibitors of viral polymerases.
• Bioconjugation & Probe Synthesis: The azido group enables click chemistry (e.g., CuAAC) for labeling, imaging, or attaching other functional molecules in biochemical studies.
• Oncology Research: Investigated for incorporation into oligonucleotides or prodrugs designed to target and disrupt cancer cell proliferation.
• Chemical Biology Tool: Serves as a substrate or inhibitor in enzymatic studies to understand nucleoside metabolism and related pathways.
• Process Chemistry & Scale-up: Employed in the development and optimization of synthetic routes for more complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3'-Azido-3'-Deoxy-5'-Iodouridine
CAS No.	2072145-33-4
Molecular Formula	C9H10IN5O5
Molecular Weight	395.11 g/mol
Synonyms	5'-Iodo-3'-azido-3'-deoxyuridine; 3'-Azido-3'-deoxy-5-iodouridine; 1-((2R,4S,5R)-4-Azido-5-(iodomethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 5-Iodo-1-(3-azido-3-deoxy-β-D-ribofuranosyl)uracil; AZDU-I; 3'-N3-5'-I-dU
EINECS	Contact for details

Quality Control

Our 3'-Azido-3'-Deoxy-5'-Iodouridine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.