Description

3'--Amino-2',3'-Dideoxy-5'-o-Methoxy Trityluridine is a high-purity, protected nucleoside derivative, a critical building block in oligonucleotide synthesis. Its value lies in enabling the precise and efficient construction of modified DNA/RNA sequences for advanced research and therapeutic development. This compound is essential for pharmaceutical R&D, biotechnology, and academic laboratories focused on antisense oligonucleotides, aptamers, and other nucleic acid-based technologies.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): As a key phosphoramidite precursor for introducing modified bases into synthetic oligonucleotides.
• Antisense Drug Development: For the research and production of therapeutic oligonucleotides designed to target specific RNA sequences.
• siRNA and miRNA Synthesis: Enabling the creation of stabilized, nuclease-resistant small interfering RNA and microRNA analogs.
• Aptamer and Diagnostic Probe Manufacturing: Used in synthesizing high-affinity nucleic acid ligands and labeled probes for detection assays.
• Academic and Industrial R&D: A vital reagent for studying nucleic acid structure, function, and for developing novel genetic tools.
• GMP-Grade Therapeutic Production: Serves as a starting material for the synthesis of active pharmaceutical ingredients (APIs) in regulated Good Manufacturing Practice environments.

Basic Information

Product Name	3'--Amino-2',3'-Dideoxy-5'-o-Methoxy Trityluridine
CAS No.	2072145-31-2
Molecular Formula	C30H31N3O6
Molecular Weight	529.59 g/mol
Synonyms	5'-O-(4-Methoxytriphenylmethyl)-3'-amino-2',3'-dideoxyuridine; 3'-Amino-2',3'-dideoxy-5'-O-MMTr-uridine; MMTr-Amino-ddU; 3'-NH2-2',3'-ddU-5'-O-MMTr; 1-[(2R,5S)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-aminooxolan-2-yl]pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our 3'--Amino-2',3'-Dideoxy-5'-o-Methoxy Trityluridine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to quality standards relevant for pharmaceutical intermediates and fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.