Description

3'-Azido-3'-Deoxy-5-Nitro-4-Deoxyuridine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a versatile building block for the creation of novel antiviral and anticancer agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside-based therapeutics. The compound's unique azido and nitro functional groups make it a valuable precursor for click chemistry and targeted drug design.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside analog prodrugs targeting viral polymerases.
• Antiviral Research: Investigated for its potential activity against a range of DNA and RNA viruses in preclinical studies.
• Oncology Drug Discovery: Used in the development of targeted chemotherapeutic agents that interfere with DNA synthesis and repair in cancer cells.
• Bioconjugation & Probe Development: The azido group enables efficient click chemistry reactions for labeling, imaging, and creating antibody-drug conjugates (ADCs).
• Biochemical Tool Compound: Employed in enzymatic studies to understand the substrate specificity and inhibition mechanisms of thymidine kinase and related enzymes.
• Academic & Contract Research: Serves as a specialized reagent for universities and CROs conducting cutting-edge medicinal chemistry programs.

Basic Information

Product Name	3'-Azido-3'-Deoxy-5-Nitro-4-Deoxyuridine
CAS No.	2072145-26-5
Molecular Formula	C9H9N5O6
Molecular Weight	283.20 g/mol
Synonyms	3'-Azido-3'-deoxy-5-nitro-4-deoxyuridine; 5-Nitro-3'-azido-3'-deoxy-4-deoxyuridine; 1-((2R,4S,5R)-4-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-nitropyrimidine-2,4(1H,3H)-dione; 3'-N3-5-NO2-dU; Azido-nitro-deoxyuridine; ANdU
EINECS	Contact for details

Quality Control

Our 3'-Azido-3'-Deoxy-5-Nitro-4-Deoxyuridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity, the product should be stored under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.