Description

2'-Deoxy-2'-Fluoro- N3-(2S)-(2-Amino-3-Carbonyl]Propyl-β-D-Arabinouridine is a high-purity, modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a critical building block in the synthesis of novel oligonucleotide therapeutics, including antisense and siRNA drugs. It is primarily sought by research institutions, pharmaceutical R&D departments, and CDMOs focused on developing next-generation targeted therapies for oncology, genetic disorders, and antiviral applications.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of fluorinated antisense oligonucleotides (ASOs) and small interfering RNA (siRNA).
• Pharmaceutical R&D: Serves as an advanced intermediate in the research and development of novel nucleoside-based prodrugs and active pharmaceutical ingredients (APIs).
• Antiviral Drug Discovery: Investigated for its potential incorporation into nucleotide analogs targeting viral polymerases.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to modulate the pharmacokinetic and binding properties of therapeutic oligonucleotides.
• Bioconjugation: The reactive amino-carbonyl propyl side chain enables site-specific conjugation for creating targeted drug delivery systems.
• Process Development: Employed by contract development and manufacturing organizations (CDMOs) for scaling up GMP-grade production of oligonucleotide therapeutics.

Basic Information

Product Name	2'-Deoxy-2'-Fluoro- N3-(2S)-(2-Amino-3-Carbonyl]Propyl-β-D-Arabinouridine
CAS No.	2072145-25-4
Molecular Formula	C₁₃H₁₇FN₄O₆
Molecular Weight	344.30 g/mol
Synonyms	2'-Deoxy-2'-fluoro-N3-[(2S)-2-amino-3-oxopropyl]-β-D-arabinouridine; 2'-F-N3-(2S)-Amino-3-oxopropyl-β-D-arabinouridine; 2'-Fluoro-2'-deoxy-N3-(L-alaninamide)arabinouridine; 2'-F-araU-N3-propionamide derivative; N3-[(2S)-2-Amino-3-oxopropyl]-2'-deoxy-2'-fluoro-β-D-arabinouridine; 2072145-25-4; Modified Arabinouridine Nucleoside
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Fluoro- N3-(2S)-(2-Amino-3-Carbonyl]Propyl-β-D-Arabinouridine is manufactured under strict quality systems to ensure batch-to-batch consistency for research and development purposes. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to high standards, this product is intended for R&D use and is not currently certified as a pharmaceutical ingredient (API) under cGMP.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.