Description

Egfr-Her2 Ex20Ins Inhibitor 1A is a potent and selective small molecule inhibitor targeting specific oncogenic mutations in non-small cell lung cancer (NSCLC). This compound is of significant interest for its potential to overcome resistance mechanisms associated with traditional EGFR tyrosine kinase inhibitors. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs engaged in the discovery and development of next-generation targeted cancer therapies.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of targeted oncology drugs.
• Preclinical Studies: For in vitro and in vivo efficacy and safety profiling against NSCLC cell lines harboring specific EGFR and HER2 exon 20 insertion mutations.
• Mechanism of Action (MoA) Studies: To investigate the biochemical pathways, binding kinetics, and resistance profiles associated with dual EGFR/HER2 inhibition.
• Combinatorial Therapy Research: Exploration of synergistic effects when used in combination with other chemotherapeutic agents or immunotherapies.
• Biomarker Discovery: Aiding in the identification and validation of predictive biomarkers for patient stratification in clinical trials.

Basic Information

Item	Details
Product Name	Egfr-Her2 Ex20Ins Inhibitor 1A
CAS No.	2068806-31-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	EGFR-HER2 Exon 20 Insertion Inhibitor 1A; EX20Inhibitor-1A; (S)-N-(5-((2-(Dimethylamino)ethyl)(methyl)amino)-2-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-1-(2-fluoro-6-hydroxyphenyl)ethan-1-amine; TAS6417; Compound 1A; EGFR/HER2 Inhibitor; NSCLC Targeted Inhibitor
EINECS	Contact for details

Quality Control

Our Egfr-Her2 Ex20Ins Inhibitor 1A is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.