Description

K-Ras(G12C) Inhibitor 6 is a potent and selective small molecule inhibitor targeting the oncogenic KRAS G12C mutant protein. This compound matters as it represents a critical tool in targeted cancer therapy research, specifically for cancers driven by this previously "undruggable" mutation. Pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology drug discovery are the primary users who need this high-purity reference standard and active pharmaceutical ingredient (API) intermediate.

Application

• Oncology Drug Discovery & Development: Serves as a key chemical entity and reference standard in the research and preclinical development of novel KRAS G12C-targeted therapeutics.
• Biochemical & Cellular Assays: Used as a potent inhibitor to study KRAS G12C signaling pathways, mechanism of action, and resistance mechanisms in cancer cell lines.
• Pharmacology & Toxicology Studies: Employed in in vitro and in vivo studies to evaluate efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of inhibitor candidates.
• API Intermediate Synthesis: Acts as a critical building block or advanced intermediate in the chemical synthesis of potential drug candidates for clinical trials.
• High-Throughput Screening (HTS): Utilized as a control compound in screening campaigns to identify new chemical scaffolds with KRAS G12C inhibitory activity.
• Structural Biology Studies: Aids in co-crystallization experiments for X-ray crystallography to understand inhibitor-protein interactions at the atomic level.

Basic Information

Product Name	K-Ras(G12C) Inhibitor 6
CAS No.	2060530-16-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	KRAS G12C Inhibitor 6; (S)-1-(4-(6-Chloro-7-(2-hydroxypropan-2-yl)quinolin-4-yl)piperazin-1-yl)-3-(4-((3R,4S)-3-fluoro-1-(2-(2-methoxyethoxy)ethyl)piperidin-4-yl)phenyl)prop-2-en-1-one; ARS-1620 analog; G12C Inhibitor; KRAS inhibitor 6; Oncogenic KRAS inhibitor; Targeted cancer therapy compound
EINECS	Contact for details

Quality Control

Our K-Ras(G12C) Inhibitor 6 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for reliable research outcomes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated analytical methods such as HPLC, NMR, and LC-MS. We adhere to relevant industry standards for research chemicals and advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is typically supplied as a solid and should be kept under inert atmosphere if indicated to prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Purity (LC-MS)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.