Description

Sorafenib Hemi-Tosylate CAS NO 2056030-06-7 is a key pharmaceutical intermediate and salt form of the multi-kinase inhibitor Sorafenib. This compound is critical for ensuring the stability, bioavailability, and manufacturability of the final active pharmaceutical ingredient (API). It is primarily required by pharmaceutical research organizations and manufacturers engaged in the development and production of targeted cancer therapeutics.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of the final Sorafenib tosylate API.
• Oncology Research: Used in preclinical and clinical research for studying kinase inhibition pathways.
• Reference Standard: Serves as a high-purity standard for analytical method development and quality control in API manufacturing.
• Formulation Development: Employed in studies to optimize drug product stability and dissolution profiles.
• Process Chemistry: Utilized in scaling up and optimizing synthetic routes for commercial production.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for GMP production.

Basic Information

Product Name	Sorafenib Hemi-Tosylate
CAS No.	2056030-06-7
Molecular Formula	C₂₁H₁₆ClF₃N₄O₃ • 0.5C₇H₈O₃S
Molecular Weight	465.83 (Free base) + 86.10 (0.5 Tosylate) = 551.93 g/mol (approx.)
Synonyms	Sorafenib Tosylate (Hemi); Sorafenib 4-Methylbenzenesulfonate (1:0.5); BAY 43-9006 Tosylate Salt; Nexavar Intermediate; 4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide Hemi(4-methylbenzenesulfonate); 1H-Pyrrole-2,5-dione, 1-[[4-(4-morpholinyl)phenyl]amino]-4-(4-pyridinyl)-, monotosylate; Sorafenib p-Toluenesulfonate Salt
EINECS	Contact for details

Quality Control

Our Sorafenib Hemi-Tosylate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets stringent specifications for pharmaceutical use. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.