Description

Methylamino-Peg5-Azide is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive methylamino group and a terminal azide. This compound is essential for creating stable, hydrophilic spacers in bioconjugation and materials science, enabling the controlled attachment of biomolecules and functional groups. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing advanced drug delivery systems, protein conjugates, and functionalized surfaces.

Application

• Bioconjugation and Crosslinking: Used to conjugate peptides, proteins, antibodies, or small molecule drugs via the amine-reactive site, with the azide group available for subsequent click chemistry (e.g., CuAAC or SPAAC).
• ADC (Antibody-Drug Conjugate) Development: Serves as a hydrophilic, flexible linker to connect cytotoxic payloads to monoclonal antibodies, improving solubility and pharmacokinetics.
• PEGylation Reagent: Acts as a functional PEG spacer to modify biomolecules, enhancing their stability, solubility, and circulation half-life while reducing immunogenicity.
• Surface Functionalization: Employed to introduce azide groups onto materials, nanoparticles, or biosensor surfaces for further bio-orthogonal modification.
• Polymer and Dendrimer Synthesis: A key building block in the stepwise construction of functionalized polymers and dendrimers via controlled click chemistry reactions.
• Diagnostic Probe Construction: Facilitates the creation of labeled probes for imaging and diagnostic assays by linking targeting moieties to reporter molecules.

Basic Information

Product Name	Methylamino-Peg5-Azide
CAS No.	2055046-24-5
Molecular Formula	C18H38N4O6
Molecular Weight	406.52 g/mol
Synonyms	mPEG5-Amine-Azide; Methylamino-PEG5-N3; N3-PEG5-Methylamine; Azido-PEG5-Methylamine; 1-Azido-3,6,9,12,15-pentaoxaoctadecan-18-amine; 18-Amino-3,6,9,12,15-pentaoxaoctadecyl azide; Heterobifunctional PEG5 Linker, Amine-Azide; 2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethylamine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Methylamino-Peg5-Azide is characterized using advanced analytical techniques to guarantee identity, purity, and functional integrity. Certificates of Analysis (COA) detailing specifications such as purity (by HPLC/NMR), functional group content, and moisture levels are available upon request. We adhere to cGMP guidelines for production where applicable to support our clients in pharmaceutical and diagnostic development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide)	≥ 90% of theoretical
Functional Group Assay (Amine)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.