Description

n-(Azido-Peg3)-n-Bis(Peg3-Acid) Hcl Salt is a heterobifunctional polyethylene glycol (PEG) derivative, specifically engineered for bioconjugation and linker applications. This compound is critical for creating stable, water-soluble crosslinks between biomolecules, such as proteins, peptides, and oligonucleotides, due to its azide and carboxylic acid functional groups. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for developing advanced therapeutics, targeted drug delivery systems, and diagnostic assays.

Application

• Bioconjugation and Crosslinking: Used as a heterobifunctional linker to covalently attach biomolecules (e.g., antibodies, peptides) to other entities like drug molecules, surfaces, or nanoparticles via click chemistry (azide) and amide bond formation (carboxylic acid).
• ADC (Antibody-Drug Conjugate) Development: Serves as a key component in the synthesis of linkers for ADCs, connecting cytotoxic payloads to monoclonal antibodies to create targeted cancer therapies.
• PEGylation Reagent: Acts as a PEGylation agent to modify proteins and peptides, enhancing their solubility, stability, and circulation half-life in vivo.
• Surface Functionalization: Employed to introduce reactive azide groups onto material surfaces (e.g., chips, beads) for subsequent bio-immobilization through click chemistry reactions.
• Polymer Chemistry: Used as a monomer or building block in the synthesis of functionalized polymers and hydrogels with tailored biological properties.
• Diagnostic Probe Synthesis: Facilitates the creation of labeled probes for imaging and diagnostic applications by linking targeting moieties to reporter molecules.

Basic Information

Product Name	n-(Azido-Peg3)-n-Bis(Peg3-Acid) Hcl Salt
CAS No.	2055042-57-2
Molecular Formula	C24H45ClN4O12
Molecular Weight	617.09 g/mol
Synonyms	Azido-PEG3-Bis(PEG3-acid) HCl Salt; 2,2'-(2-(2-(2-Azidoethoxy)ethoxy)ethylazanediyl)diacetic acid hydrochloride; 1-Azido-3,6,9-trioxa-12-azaheptadecanedioic acid hydrochloride; N-(Azido-PEG3)-N-bis(PEG3-acid) hydrochloride; Heterobifunctional PEG Azide Acid HCl Salt; 15-Azido-4,7,10,13-tetraoxa-3-azahexadecanedioic acid hydrochloride; Azido-PEG3-tris(acetic acid) HCl Salt (common alias); PEG-based Azido Acid Crosslinker HCl Salt
EINECS	Contact for details

Quality Control

Our n-(Azido-Peg3)-n-Bis(Peg3-Acid) Hcl Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the primary container in a sealed secondary container with an appropriate desiccant. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.