Description

Azido-Peg3-Sulfone-Peg4-T-Butyl Ester is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an azide group and a sulfone-activated ester, separated by distinct PEG spacer arms. This compound matters for its precise reactivity, enabling efficient, site-specific bioconjugation and click chemistry applications in advanced research and development. It is primarily needed by pharmaceutical researchers and biotech companies developing antibody-drug conjugates (ADCs), peptide therapeutics, and diagnostic probes, as well as by academic institutions engaged in materials science and chemical biology.

Application

• Site-specific bioconjugation for the development of Antibody-Drug Conjugates (ADCs) and other targeted therapeutics.
• Functionalization of nanoparticles, surfaces, and biomaterials via click chemistry (CuAAC or strain-promoted) for diagnostic and therapeutic platforms.
• Synthesis of PEGylated peptides and proteins to enhance solubility, stability, and pharmacokinetic properties.
• Preparation of fluorescent or affinity probes for cellular imaging and target identification studies.
• Crosslinking agent in the fabrication of hydrogels and polymer networks with controlled degradation profiles.
• Tool compound in chemical biology for labeling and studying biomolecular interactions.

Basic Information

Product Name	Azido-Peg3-Sulfone-Peg4-T-Butyl Ester
CAS No.	2055023-76-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Azido-PEG3-Sulfone-PEG4-t-butyl ester; N3-PEG3-Sulfone-PEG4-OtBu; Azido-PEG3-Sulfone-PEG4-OtBu; Azido-triethyleneglycol-sulfone-tetraethyleneglycol-t-butyl ester; PEG-based heterobifunctional crosslinker, azide and sulfone; t-Butyl 3-azido-2,5,8,11,14,17,20,23-octaoxa-4-thiahexacosan-26-oate S,S-dioxide (theoretical); Azido-PEG-Sulfone-PEG-t-Butyl Ester
EINECS	Contact for details

Quality Control

Our Azido-Peg3-Sulfone-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. For long-term storage, desiccate to protect against moisture. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.