Description

Azido-PEG8-PFP Ester is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an azide group and a pentafluorophenyl (PFP) ester. This compound is a critical reagent for bioorthogonal click chemistry, enabling efficient, site-specific conjugation under mild, aqueous conditions. It is primarily utilized by researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced materials science to create stable, well-defined molecular constructs.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific coupling of payloads (e.g., toxins, dyes, drugs) to proteins, antibodies, or peptides via strain-promoted azide-alkyne cycloaddition (SPAAC).
• PEGylation and Linker Chemistry: Acts as a functionalized PEG spacer to improve pharmacokinetics, solubility, and stability of therapeutic biomolecules.
• Surface Functionalization and Biomaterial Engineering: Modification of nanoparticles, hydrogels, and diagnostic surfaces with bioactive ligands for targeted delivery and sensing.
• Polymer Chemistry and Dendrimer Synthesis: Building block for creating functionalized polymers and dendritic structures with controlled architecture.
• Proteomics and Chemical Biology: Tool for labeling and enriching biomolecules for mass spectrometry analysis and activity-based protein profiling.
• Diagnostic Reagent Formulation: Development of contrast agents and fluorescent probes for in vitro and in vivo imaging applications.

Basic Information

Product Name	Azido-PEG8-PFP Ester
CAS No.	2055014-62-3
Molecular Formula	C31H44F5N3O12
Molecular Weight	745.7 g/mol
Synonyms	Azido-PEG8-PFP ester; 2,5-Dioxopyrrolidin-1-yl 3-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate; PFP-PEG8-N3; α-Azido-ω-pentafluorophenyl ester octaethylene glycol; Pentafluorophenyl-PEG8-azide; N3-PEG8-PFP; Azido-PEG8-OCO-PFP; Azido-PEG8-pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our Azido-PEG8-PFP Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.