Description

Azide-Peg3-L-Alanine-Fmoc is a specialized bifunctional linker molecule designed for advanced bioconjugation and peptide synthesis. This compound is critical for researchers and manufacturers requiring precise, site-specific modifications of biomolecules, such as peptides and proteins, through click chemistry. It is an essential building block for pharmaceutical R&D, particularly in the development of antibody-drug conjugates (ADCs), peptide-based therapeutics, and diagnostic probes.

Application

• Peptide Synthesis: Used as an Fmoc-protected amino acid derivative for the solid-phase synthesis of peptides containing azide functional groups for subsequent conjugation.
• Bioconjugation & ADC Development: Enables site-specific "click chemistry" (CuAAC or SPAAC) coupling of payloads, fluorophores, or other functional units to peptides, proteins, or antibodies.
• Chemical Biology Probes: Serves as a key reagent for synthesizing activity-based probes and affinity tags to study protein function and interactions.
• Polymer & Material Science: Acts as a functional monomer or cross-linker for creating smart biomaterials, hydrogels, and surfaces with bio-orthogonal reactivity.
• Drug Discovery: Facilitates the construction of complex molecular architectures and libraries for high-throughput screening and lead optimization.

Basic Information

Product Name	Azide-Peg3-L-Alanine-Fmoc
CAS No.	2054345-69-4
Molecular Formula	C26H32N4O7
Molecular Weight	512.56 g/mol
Synonyms	Fmoc-L-Ala(Peg3-N3)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-L-alanine; Fmoc-8-amino-3,6-dioxaoctanoic acid (Azide); Azido-PEG3-Fmoc-L-Alanine; Fmoc-N-amido-PEG3-azide; Fmoc-L-Alanine-PEG3-azide; Azido-PEG3-C2-Fmoc-L-Ala-OH
EINECS	Contact for details

Quality Control

Our Azide-Peg3-L-Alanine-Fmoc is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, Acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.