Description

Azido-Tris(Ethylenoxy)-L-Alanine Tfa Salt is a specialized, non-natural amino acid derivative designed for advanced bioconjugation and peptide engineering. This compound matters for its unique bifunctional structure, featuring an azide group for copper-free "click" chemistry and a polyether spacer that enhances solubility and reduces steric hindrance. It is primarily needed by researchers and manufacturers in the pharmaceutical and biotechnology industries for the development of antibody-drug conjugates (ADCs), peptide-based therapeutics, and diagnostic probes.

Application

• Bioconjugation Reagent: Used as a key building block for site-specific modification of proteins, antibodies, and peptides via strain-promoted azide-alkyne cycloaddition (SPAAC).
• ADC (Antibody-Drug Conjugate) Linker-Payload Synthesis: Serves as a functionalized spacer to connect cytotoxic drugs to monoclonal antibodies, enabling targeted cancer therapy.
• Peptide Engineering: Incorporated into synthetic peptides to introduce polyethylene glycol (PEG)-like properties, improving pharmacokinetic profiles such as solubility and circulation half-life.
• Diagnostic Probe Development: Utilized to label biomolecules with fluorescent dyes or other reporter groups for imaging and detection applications.
• Material Science & Surface Functionalization: Applied to modify surfaces or polymers with bio-active moieties for creating smart biomaterials and biosensors.
• Chemical Biology Research: Acts as a versatile tool for studying protein-protein interactions, cellular trafficking, and metabolic pathways through bioorthogonal labeling.

Basic Information

Product Name	Azido-Tris(Ethylenoxy)-L-Alanine Tfa Salt
CAS No.	2054345-67-2
Molecular Formula	C₁₄H₂₄N₄O₈ • C₂HF₃O₂
Molecular Weight	Contact for details
Synonyms	N₃-PEG₃-L-Alanine TFA Salt; Azido-PEG₃-L-Ala-OH•TFA; 2-Azidoethoxyethoxyethoxy-L-alanine Trifluoroacetate; Fmoc-L-Ala(N₃-PEG₃-OH)-OH building block derivative; N-(2-(2-(2-Azidoethoxy)ethoxy)ethyl)-L-alanine TFA salt; Azido-triethylene glycol-L-alanine; PEGylated azido alanine TFA salt
EINECS	Contact for details

Quality Control

Our Azido-Tris(Ethylenoxy)-L-Alanine Tfa Salt is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The product is moisture-sensitive and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.