Description

Mutated Egfr-In-2 (Compound 91) is a potent and selective small-molecule inhibitor designed to target specific oncogenic mutations in the Epidermal Growth Factor Receptor (EGFR). This compound matters for researchers and developers as a critical tool compound for investigating resistance mechanisms and developing next-generation targeted cancer therapies. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, particularly in the areas of non-small cell lung cancer (NSCLC) and other EGFR-driven malignancies.

Application

• Biochemical Research: Used as a reference standard and tool compound for in vitro enzymatic assays to study the inhibition kinetics of mutated EGFR isoforms.
• Cell-Based Studies: Applied in cell culture experiments to assess the potency and selectivity against cancer cell lines harboring specific EGFR mutations (e.g., T790M, L858R, exon 19 deletions).
• Mechanism of Action (MoA) Research: Serves as a key molecule for elucidating drug resistance pathways and exploring combination therapy strategies in preclinical models.
• Lead Optimization: Provides a valuable chemical scaffold for medicinal chemistry programs aimed at improving pharmacokinetic properties and therapeutic index of EGFR inhibitors.
• Preclinical Development: Supports proof-of-concept studies in animal models to evaluate efficacy and safety profiles of novel therapeutic candidates.

Basic Information

Product Name	Mutated Egfr-In-2 (Compound 91)
CAS No.	2050906-97-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Compound 91; EGFR Mutant Inhibitor-2; Mutated EGFR Inhibitor 2; EGFR-TKI research compound; Oncogenic EGFR inhibitor; Tyrosine kinase inhibitor (research grade); Targeted therapy research chemical
EINECS	Contact for details

Quality Control

Our Mutated Egfr-In-2 (Compound 91) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be sealed under dry conditions and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.