Description

(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,3-D]Pyrimidin-7-Yl)-5[(R)-Hydroxy(Phenyl)Methyl]Tetrahydrofuran-3,4-Diol is a high-purity nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel antiviral and anticancer therapeutics, particularly in the development of modified oligonucleotides and prodrugs. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to innovate in targeted therapies.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Antiviral Drug Development: Research and production of prodrugs targeting viral polymerases, with potential applications against a range of viruses.
• Oncology Research: Utilized in the creation of chemotherapeutic compounds designed to interfere with cancer cell DNA/RNA synthesis.
• Oligonucleotide Synthesis: Serves as a modified nucleoside precursor for antisense oligonucleotides and siRNA therapeutics.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and cGMP manufacturing for clinical trial material and commercial API production.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies to understand biological pathways and mechanisms of action.

Basic Information

Product Name	(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,3-D]Pyrimidin-7-Yl)-5[(R)-Hydroxy(Phenyl)Methyl]Tetrahydrofuran-3,4-Diol
CAS No.	2040291-27-6
Molecular Formula	C17H18N4O5
Molecular Weight	358.35 g/mol
Synonyms	7-((2R,3R,4S,5R)-3,4-Dihydroxy-5-((R)-hydroxy(phenyl)methyl)tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 4-Amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-((R)-hydroxy(phenyl)methyl)tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidine; Nucleoside Analog Intermediate; Pyrrolo[2,3-d]pyrimidine nucleoside derivative; (2R,3R,4S,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-hydroxy(phenyl)methyl)tetrahydrofuran-3,4-diol
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and cGMP manufacturing. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support regulatory filings with full traceability and data packages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.