Description

n-[1-[(3R)-1-(1-Oxo-2-Propen-1-Yl)-3-Piperidinyl]-3-(4-Phenoxyphenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Yl]- 2-Propenamide is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value in medicinal chemistry research and development, particularly for its potential role as a key building block in the synthesis of targeted therapeutic agents. It is primarily sought by research institutions and pharmaceutical companies engaged in the discovery and development of novel small-molecule drugs, especially within oncology and other disease areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Its pyrazolo[3,4-d]pyrimidine core is a privileged structure in the design of protein kinase inhibitors, a major class of therapeutics.
• Biochemical Tool Compound: Employed in biochemical assays and as a probe to study specific biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for cutting-edge research in synthetic organic chemistry and pharmacology.

Basic Information

Item	Details
Product Name	n-[1-[(3R)-1-(1-Oxo-2-Propen-1-Yl)-3-Piperidinyl]-3-(4-Phenoxyphenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Yl]- 2-Propenamide
CAS No.	2031255-27-1
Molecular Formula	C31H28N6O3
Molecular Weight	532.60 g/mol
Synonyms	(R)-N-(1-(1-Acryloylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)acrylamide; 2031255-27-1; UNII-9J2I3F8T0N; 9J2I3F8T0N; CHEMBL3186660; AKOS040759393; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-[1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)-, 2-propenamide
EINECS	Contact for details

Quality Control

Our n-[1-[(3R)-1-(1-Oxo-2-Propen-1-Yl)-3-Piperidinyl]-3-(4-Phenoxyphenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Yl]- 2-Propenamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.