Description

5-Hydroxy-2'-o-Methyluridine is a modified nucleoside derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound is valued for its role as a key building block and a critical reference standard in the synthesis and study of oligonucleotides, particularly in the development of mRNA-based therapeutics and vaccines. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on nucleic acid chemistry, antiviral drug discovery, and epigenetics.

Application

• Oligonucleotide Synthesis: A crucial phosphoramidite precursor for the solid-phase synthesis of modified RNA strands, enabling the introduction of specific structural motifs.
• mRNA Therapeutic Research: Serves as a critical raw material in the development and optimization of modified mRNA constructs to enhance stability and translational efficiency.
• Antiviral Drug Discovery: Investigated as a potential nucleoside analog for inhibiting viral replication mechanisms in various RNA viruses.
• Biochemical Reference Standard: Used as a high-purity analytical standard for the quantification and characterization of modified nucleosides in complex biological samples via HPLC or LC-MS.
• Enzymology Studies: Employed in studies of enzyme kinetics and specificity, particularly for methyltransferases and other RNA-modifying enzymes.
• Epigenetics & RNA Biology: A tool for researching the function and dynamics of post-transcriptional RNA modifications and their role in cellular regulation.

Basic Information

Product Name	5-Hydroxy-2'-o-Methyluridine
CAS No.	2030403-78-0
Molecular Formula	C11H16N2O8
Molecular Weight	304.26 g/mol
Synonyms	2'-O-Methyl-5-hydroxyuridine; 5-Hydroxy-2'-O-methyluridine; 5-OH-2'-OMe-uridine; Uridine, 5-hydroxy-2'-O-methyl-; 2'-O-Methyl-5-OH-uridine; 5-Hydroxy-2'-methoxyuridine; 2'-Methoxy-5-hydroxyuridine
EINECS	Contact for details

Quality Control

Our 5-Hydroxy-2'-o-Methyluridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.