Description

Azido-PEG4-(CH2)3OH is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive azide group and a hydroxyl-terminated alkyl chain. This compound is essential for creating stable, hydrophilic spacers in bioconjugation and materials science, enabling click chemistry reactions with alkynes for precise molecular assembly. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing antibody-drug conjugates (ADCs), PEGylated therapeutics, and functionalized surfaces.

Application

• Bioconjugation & ADC Development: Serves as a hydrophilic linker to connect cytotoxic drugs to monoclonal antibodies via copper-free or copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• PEGylation Reagent: Used to modify proteins, peptides, and nanoparticles to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Polymer & Materials Science: Acts as a building block for synthesizing functionalized hydrogels, smart polymers, and surface coatings with tailored properties.
• Diagnostic Probe Synthesis: Facilitates the attachment of imaging agents (e.g., fluorophores, radiolabels) to targeting molecules for in vitro and in vivo diagnostics.
• Crosslinking Agent: Enables the formation of stable networks in biomaterials and drug delivery systems through reaction with complementary functional groups.
• Chemical Biology Tool: Employed in activity-based protein profiling (ABPP) and the study of biomolecular interactions via bioorthogonal chemistry.

Basic Information

Item	Details
Product Name	Azido-PEG4-(CH2)3OH
CAS No.	2028281-87-8
Molecular Formula	C15H31N3O6
Molecular Weight	349.42 g/mol
Synonyms	3-Azidopropyl-PEG4-OH; 3-Azidopropyl-tetraethylene glycol; Azido-PEG4-propanol; 11-Azido-3,6,9-trioxaundecan-1-ol; 1-Azido-3,6,9,12-tetraoxapentadecan-15-ol; N3-PEG4-C3-OH; Azido-PEG4-C3-Alcohol; Heterobifunctional PEG Azide Linker
EINECS	Contact for details

Quality Control

Our Azido-PEG4-(CH2)3OH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical research and production applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.