Description

1-(2-o-Acetyl-3-o-Benzyl-4-C-Methanesulfonoxymethyl-5-o-Methanesulfonyl-β-D-Ribofuranosyl)Thymine is a sophisticated nucleoside derivative and a key synthetic intermediate in advanced pharmaceutical research. This compound is critical for the development of novel antiviral and anticancer therapeutics, particularly in the synthesis of modified nucleoside analogs. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the production of high-value active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Antiviral Drug Research: Used in the development of prodrugs and modified nucleosides targeting viral polymerases for diseases such as hepatitis and herpes.
• Oncology Research: Serves as a precursor in the creation of chemotherapeutic agents that interfere with DNA synthesis in rapidly dividing cancer cells.
• Prodrug Synthesis: The methanesulfonyl and acetyl protecting groups make it a versatile intermediate for constructing prodrugs with enhanced bioavailability.
• Biochemical Research: Employed in studies investigating DNA/RNA metabolism, enzyme inhibition, and the mechanism of action of nucleoside analogs.
• Fine Chemical Production: Supplied to contract manufacturing organizations (CMOs) for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Item	Detail
Product Name	1-(2-o-Acetyl-3-o-Benzyl-4-C-Methanesulfonoxymethyl-5-o-Methanesulfonyl-β-D-Ribofuranosyl)Thymine
CAS No.	293751-04-9
Molecular Formula	C22H28N2O11S2
Molecular Weight	560.59 g/mol
Synonyms	1-(2-O-Acetyl-3-O-benzyl-4-C-methanesulfonoxymethyl-5-O-methanesulfonyl-β-D-ribofuranosyl)thymine; 1-[2-O-Acetyl-3-O-benzyl-4-C-[(methylsulfonyl)oxy]methyl-5-O-(methylsulfonyl)-β-D-ribofuranosyl]thymine; 1-(2-O-Acetyl-3-O-benzyl-4-C-(methylsulfonyloxymethyl)-5-O-methylsulfonyl-β-D-ribofuranosyl)thymine; Thymine β-D-ribofuranoside derivative; Nucleoside intermediate 293751-04-9; CAS 293751-04-9
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to stringent quality protocols suitable for pharmaceutical research and development. Each batch is characterized and tested to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay by HPLC, related substances, and residual solvents. Our quality system supports development under cGMP guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.