Description

3-Bromo-2,4,5,6-Tetrafluorobenzoyl Chloride is a highly reactive and versatile fluorinated aromatic building block. This compound is critical for introducing the 3-bromo-2,4,5,6-tetrafluorobenzoyl moiety into target molecules, enabling precise structural modifications. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates, active ingredients, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a perfluorinated aromatic core with orthogonal reactivity for further functionalization.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), where fluorine substitution improves charge transport and stability.
• Polymer Modification: Employed to introduce fluorinated benzoyl groups into polymer chains, altering surface properties, chemical resistance, and thermal stability for high-performance materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille), allowing for the construction of complex biaryl systems.
• Derivatization Agent: Used in analytical chemistry to derivative amines, alcohols, or other nucleophiles for detection or analysis due to the high reactivity of the acid chloride group.

Basic Information

Item	Details
Product Name	3-Bromo-2,4,5,6-Tetrafluorobenzoyl Chloride
CAS No.	292621-46-6
Molecular Formula	C7BrClF4O
Molecular Weight	291.43 g/mol
Synonyms	2,4,5,6-Tetrafluoro-3-bromobenzoyl chloride; 3-Bromo-2,4,5,6-tetrafluorobenzoic acid chloride; Benzoyl chloride, 3-bromo-2,4,5,6-tetrafluoro-; 3-Bromotetrafluorobenzoyl chloride; (3-Bromo-2,4,5,6-tetrafluorophenyl)carbonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Bromo-2,4,5,6-Tetrafluorobenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its moisture-sensitive (hygroscopic) nature, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.