Description

Bicyclo[2.2.1]Heptane-7-Carbonyl Fluoride, 1,7-Dimethyl-2-Oxo-, (1R,4R,7R)- (9Ci) is a high-purity, stereochemically defined fluorinated building block essential for advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of novel pharmaceuticals and agrochemicals, where its unique bicyclic structure and carbonyl fluoride moiety enable precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex, bioactive molecules with high stereochemical fidelity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where its structural rigidity can enhance biological activity and environmental stability.
• Fluorination Chemistry: Serves as a versatile source of the carbonyl fluoride (-COF) functional group for introducing fluorine atoms or fluorinated motifs into target molecules, a common strategy to modulate lipophilicity and metabolic stability.
• Asymmetric Synthesis: Employed as a chiral scaffold or auxiliary in catalytic asymmetric reactions to induce high enantioselectivity in the formation of new carbon-carbon or carbon-heteroatom bonds.
• Material Science Precursor: Potential use in the synthesis of specialized polymers or coatings where the bicyclic structure can impart unique thermal or mechanical properties.
• Chemical Biology Probes: Useful for creating activity-based probes or labeled compounds for studying enzyme mechanisms and biological pathways.

Basic Information

Item	Details
Product Name	Bicyclo[2.2.1]Heptane-7-Carbonyl Fluoride, 1,7-Dimethyl-2-Oxo-, (1R,4R,7R)- (9Ci)
CAS No.	289722-46-9
Molecular Formula	C10H13FO2
Molecular Weight	184.21 g/mol
Synonyms	(1R,4R,7R)-1,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-7-carbonyl fluoride; endo,endo-1,7-Dimethyl-2-oxonorbornane-7-carbonyl fluoride; 7-Carboxyfluoride-1,7-dimethyl-2-norbornanone; (1R,4R,7R)-7-(Fluorocarbonyl)-1,7-dimethylbicyclo[2.2.1]heptan-2-one; Fluorocarbonyl-dimethyl-norbornanone
EINECS	Contact for details

Quality Control

Our Bicyclo[2.2.1]Heptane-7-Carbonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC and structural confirmation by NMR and IR spectroscopy, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.