Description

Thymidine, 5'-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-3'-o-[(1,1-Dimethylethyl)Diphenylsilyl]- (9Ci) is a sophisticated, high-purity nucleoside derivative, specifically designed as a key protected intermediate in advanced organic synthesis. This compound is critically important for enabling precise and efficient chemical transformations in the production of complex biomolecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in oligonucleotide synthesis, prodrug development, and the creation of novel therapeutic agents, where its protective groups ensure selective reactivity and high yields.

Application

• Oligonucleotide Synthesis: Serves as a crucial, protected building block (phosphoramidite precursor) in the solid-phase synthesis of DNA and RNA strands for research, diagnostics, and therapeutics.
• Antiviral & Anticancer Prodrug Development: Used in the research and synthesis of nucleoside analog prodrugs, where the protective groups allow for targeted activation within cells.
• Medicinal Chemistry & Drug Discovery: Acts as an advanced intermediate for modifying the sugar moiety of nucleosides to improve pharmacokinetic properties like stability and bioavailability.
• Bioconjugation & Labeling: Provides a functional handle for attaching reporter molecules (e.g., fluorophores, biotin) to nucleosides for imaging and detection studies.
• Chemical Biology Research: Employed in studying enzyme mechanisms (e.g., polymerases, kinases) and exploring nucleic acid metabolism pathways.
• Process Development & Scale-up: Used in pilot plants and manufacturing settings to develop robust synthetic routes for active pharmaceutical ingredients (APIs) containing modified thymidine.

Basic Information

Item	Details
Product Name	Thymidine, 5'-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-3'-o-[(1,1-Dimethylethyl)Diphenylsilyl]- (9Ci)
CAS No.	289681-49-8
Molecular Formula	C46H48N2O7Si
Molecular Weight	768.98 g/mol
Synonyms	5'-O-DMT-3'-O-TBDPS-thymidine; 5'-O-(4,4'-Dimethoxytrityl)-3'-O-(tert-butyldiphenylsilyl)thymidine; 3'-O-TBDPS-5'-O-DMT-Thymidine; N3-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) (related precursor); DMT-T-dTBDPS; Thymidine DMT TBDPS derivative; Protected Thymidine intermediate; 1-[(2R,3S,5R)-3-[[tert-Butyl(diphenyl)silyl]oxy]-5-[bis(4-methoxyphenyl)-phenylmethoxy]methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate undergoes rigorous analytical testing to ensure identity, purity, and consistency suitable for sensitive synthetic applications. Our quality protocols are designed to meet the exacting standards of pharmaceutical R&D and GMP-guided production. A comprehensive Certificate of Analysis (COA) detailing purity (HPLC), identity (NMR, MS), and impurity profiles is provided with each shipment to support your regulatory and quality documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. For long-term storage, consider sealing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.