Description

Canertinib Dihydrochloride is a potent and selective small-molecule inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound is a critical research tool and pharmaceutical intermediate for developing targeted cancer therapies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotech companies engaged in oncology drug discovery and preclinical studies.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel EGFR-targeted anticancer agents.
• Biochemical Assays: Used as a selective inhibitor in enzymatic and cellular assays to study EGFR signaling pathways, mechanism of action, and drug resistance.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate the efficacy, pharmacokinetics, and toxicology profiles of EGFR inhibitor candidates.
• Chemical Synthesis: Acts as a high-value building block for the synthesis of more complex molecules or prodrugs in medicinal chemistry programs.
• Quality Control: Functions as a certified reference material (CRM) for the analytical testing and validation of drug substances and finished dosage forms.

Basic Information

Product Name	Canertinib Dihydrochloride
CAS No.	289499-45-2
Molecular Formula	C24H25ClFN5O3 • 2HCl
Molecular Weight	562.86 g/mol (for dihydrochloride salt)
Synonyms	CI-1033; PD 183805; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride; (E)-Canertinib dihydrochloride; Canertinib HCl; CI1033; PD183805
EINECS	Contact for details

Quality Control

Our Canertinib Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Assay (on anhydrous basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.