Description

Cediranib CAS NO 288383-20-0 is a potent and selective small-molecule inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases. This compound is a critical research tool and active pharmaceutical ingredient (API) for the development of targeted cancer therapies. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on oncology, angiogenesis, and kinase signaling pathways.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active ingredient in preclinical and clinical studies for anti-cancer drugs.
• Oncology Drug Discovery: Used as a potent inhibitor in assays to study VEGF receptor (VEGFR) signaling and tumor angiogenesis.
• Biochemical Research: Employed as a selective tyrosine kinase inhibitor to investigate cellular pathways related to growth and proliferation.
• Reference Standard: Provides a high-purity benchmark for analytical method development, validation, and quality control in API manufacturing.
• Formulation Development: Used in the development of various dosage forms, including capsules and tablets, for clinical trials.

Basic Information

Product Name	Cediranib
CAS No.	288383-20-0
Molecular Formula	C₂₀H₁₉FN₄O
Molecular Weight	350.39 g/mol
Synonyms	AZD2171; Recentin; 4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline; N-[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-5-quinazolinyl]-acetamide (obsolete); UNII-6H8V27S4ZS
EINECS	Contact for details

Quality Control

Our Cediranib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, MS) to ensure it meets rigorous pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified requirements for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.