Description

4-[(6,7-Dimethoxy-4-Quinazolinyl)Oxy]Aniline is a high-purity, advanced pharmaceutical intermediate characterized by its quinazoline-based molecular structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of targeted therapeutic agents. It is primarily required by pharmaceutical R&D and manufacturing sectors for the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of small-molecule kinase inhibitors and other targeted cancer therapies.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold in multi-step synthetic routes for final API production.
• Biochemical Research: Employed as a reference standard or probe compound in biochemical and pharmacological assays.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4-[(6,7-Dimethoxy-4-Quinazolinyl)Oxy]Aniline
CAS No.	286371-71-9
Molecular Formula	C₁₆H₁₅N₃O₃
Molecular Weight	297.31 g/mol
Synonyms	4-(6,7-Dimethoxyquinazolin-4-yloxy)aniline; 4-Amino-4'-(6,7-dimethoxyquinazolin-4-yloxy)diphenyl ether (incorrect but common misnomer); 4-(4-Aminophenoxy)-6,7-dimethoxyquinazoline; 286371-71-9; 4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]benzenamine; Aniline, 4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-
EINECS	Contact for details

Quality Control

Our 4-[(6,7-Dimethoxy-4-Quinazolinyl)Oxy]Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) with batch-specific data are provided to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.