Description

Rucaparib is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor, a critical class of targeted cancer therapeutics. It is primarily used in the treatment of advanced ovarian, prostate, and pancreatic cancers, particularly in patients with specific genetic mutations like BRCA. This high-purity active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers and research institutions developing and producing innovative oncology treatments.

Application

• Primary Active Pharmaceutical Ingredient (API) in the formulation of oral anti-cancer medications.
• Key component in targeted therapy for advanced ovarian cancer with BRCA mutations or homologous recombination deficiency (HRD).
• Research and development of novel PARP inhibitor-based combination therapies for prostate and pancreatic cancers.
• Manufacturing of reference standards and impurities for analytical method development and quality control.
• Pre-clinical and clinical research studies investigating mechanisms of DNA damage repair.
• Production of finished dosage forms such as film-coated tablets for commercial pharmaceutical supply.

Basic Information

Item	Detail
Product Name	Rucaparib
CAS No.	283173-50-2
Molecular Formula	C19H18F2N4O
Molecular Weight	356.37 g/mol
Synonyms	AG-014699; PF-01367338; Rubraca (trade name); 8-Fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one; PARP Inhibitor AG014699; (8-Fluoro-1,3,4,5-tetrahydro-2H-azepino[5,4,3-cd]indol-2-yl)(4-((methylamino)methyl)phenyl)methanone
EINECS	Contact for details

Quality Control

Our Rucaparib is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and strength. We provide full traceability and Certificates of Analysis (COA) that detail compliance with in-house specifications aligned with ICH guidelines. Our commitment to cGMP standards ensures reliability for critical drug development and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.10%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.