Description

tert-Butyl 4-(Chlorocarbonyl)-Piperidine-1-Carboxylate is a versatile and highly reactive piperidine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, featuring both a reactive acid chloride group and a Boc-protected amine, enabling efficient, multi-step construction of complex molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of piperidine-based drug candidates, including kinase inhibitors, receptor antagonists, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Building block for creating novel pesticides, herbicides, and fungicides that incorporate the piperidine moiety for enhanced biological activity.
• Peptide Mimetics & Conjugation: Used to introduce the piperidine scaffold into peptide backbones or for conjugating payloads in drug discovery, particularly in medicinal chemistry.
• Custom Chemical & Contract Manufacturing: A valuable starting material for custom synthesis and scale-up projects requiring specific, functionalized heterocyclic structures.
• Research & Development: Employed in academic and industrial R&D labs for exploring new chemical entities and reaction pathways in organic chemistry.

Basic Information

Product Name	tert-Butyl 4-(Chlorocarbonyl)-Piperidine-1-Carboxylate
CAS No.	280115-99-3
Molecular Formula	C11H18ClNO3
Molecular Weight	247.72 g/mol
Synonyms	1-Boc-4-(Chlorocarbonyl)piperidine; 4-(Chloroformyl)-1-piperidinecarboxylic Acid tert-Butyl Ester; 1-(tert-Butoxycarbonyl)-4-piperidinecarbonyl Chloride; tert-Butyl 4-(Chloroformyl)piperidine-1-carboxylate; 4-Carbamoyl-1-piperidinecarboxylic Acid tert-Butyl Ester Hydrochloride (precursor related); N-Boc-isonipecotyl chloride; Boc-4-piperidinecarbonyl chloride
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Chlorocarbonyl)-Piperidine-1-Carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) and highly volatile nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent decomposition and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.