Description

Cyclobutanecarbonyl Fluoride, 1-(Trifluoromethyl)- (9Ci) is a specialized fluorinated building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a reactive acyl fluoride group and a trifluoromethylated cyclobutane ring, enabling the efficient introduction of both fluorinated motifs and strained ring systems into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced metabolic stability and bioavailability. The CAS number for this material is 277756-42-0.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics where the cyclobutane scaffold and fluorine atoms can modulate potency and ADME properties.
• Agrochemical Active Ingredient Development: Used in constructing advanced intermediates for next-generation herbicides, fungicides, and insecticides, leveraging the biological activity imparted by the trifluoromethyl group.
• Material Science Research: Serves as a precursor for fluorinated polymers or specialty chemicals with unique surface properties, thermal stability, or chemical resistance.
• PET (Positron Emission Tomography) Tracer Synthesis: The acyl fluoride moiety can be utilized in rapid, late-stage fluorination reactions for labeling molecules with fluorine-18, a critical radioisotope for medical imaging.
• Cross-Coupling & Functionalization Reactions: The reactive functional groups make it a versatile substrate for palladium-catalyzed cross-couplings and nucleophilic acyl substitution reactions to create complex molecular architectures.

Basic Information

Product Name	Cyclobutanecarbonyl Fluoride, 1-(Trifluoromethyl)- (9Ci)
CAS No.	277756-42-0
Molecular Formula	C6H6F4O
Molecular Weight	170.11 g/mol
Synonyms	1-(Trifluoromethyl)cyclobutanecarbonyl fluoride; 1-(Trifluoromethyl)cyclobutanecarboxylic acid fluoride; 1-Trifluoromethylcyclobutane-1-carbonyl fluoride; Cyclobutanecarbonyl fluoride, 1-(trifluoromethyl)-; (1-(Trifluoromethyl)cyclobutyl)carbonyl fluoride
EINECS	Contact for details

Quality Control

Every batch of Cyclobutanecarbonyl Fluoride, 1-(Trifluoromethyl)- (9Ci) undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality management system is designed to meet the stringent requirements of research and scale-up applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as assay (by GC or NMR), identity confirmation (by FT-IR and/or 1H/19F NMR), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and highly volatile nature, this material must be stored under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Allow the sealed container to reach room temperature before opening to prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.