Description

Bicyclo[1.1.1]pentane-1-carbonyl chloride, 3-propyl- (9Ci) is a highly functionalized, strained bicyclic building block of significant interest in modern organic synthesis and medicinal chemistry. Its unique three-dimensional, rigid scaffold and reactive acid chloride group make it a valuable intermediate for constructing complex molecular architectures that are difficult to access with conventional flat ring systems. This compound is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing new active ingredients with improved properties.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in fragment-based drug discovery and for creating bioisosteres of benzene rings to improve metabolic stability, solubility, and potency.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the bicyclo[1.1.1]pentane core can impart favorable physicochemical properties.
• Materials Science: Serves as a precursor for monomers and cross-linkers in the synthesis of polymers with unique mechanical or optical properties due to its strained, three-dimensional geometry.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed as a linker or spacer component to connect warheads to E3 ligase ligands, leveraging its rigidity and stability.
• Ligand and Catalyst Development: Useful for constructing novel, sterically demanding ligands for asymmetric catalysis and organometallic complexes.
• Peptide Mimetics: Incorporated into peptide chains to induce specific conformational constraints and enhance proteolytic stability.

Basic Information

Item	Details
Product Name	Bicyclo[1.1.1]pentane-1-carbonyl chloride, 3-propyl- (9Ci)
CAS No.	271768-24-2
Molecular Formula	C9H13ClO
Molecular Weight	172.65 g/mol
Synonyms	3-Propylbicyclo[1.1.1]pentane-1-carbonyl chloride; 1-(Chlorocarbonyl)-3-propylbicyclo[1.1.1]pentane; 3-Propylbicyclo[1.1.1]pentanecarboxylic acid chloride; Propyl-BCP-COCl; BCP(Propyl) acid chloride
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity for research and development applications. Our products undergo comprehensive analytical testing, including NMR, HPLC, and GC analysis, to verify identity and purity. A Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and moisture-sensitive nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.