Description

2-Propynoyl Chloride, 3-Cyclopropyl- (9Ci) is a specialized organic acid chloride building block featuring a reactive propynoyl chloride moiety attached to a cyclopropyl ring. This compound matters for its unique structural motif, which enables the efficient synthesis of complex molecules containing cyclopropyl and alkyne functionalities in a single step. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) with cyclopropyl groups, potentially targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the cyclopropyl moiety can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for monomers or cross-linking agents in the development of specialty polymers with tailored thermal or mechanical properties.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation, enabling the labeling or modification of biomolecules (proteins, peptides) via click chemistry or amide bond formation.
• Ligand & Catalyst Development: Employed in the preparation of novel organometallic complexes and chiral ligands for asymmetric catalysis.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Propynoyl Chloride, 3-Cyclopropyl- (9Ci)
CAS No.	268542-56-9
Molecular Formula	C6H5ClO
Molecular Weight	128.56 g/mol
Synonyms	3-Cyclopropylpropiolyl chloride; 3-Cyclopropyl-2-propynoyl chloride; Cyclopropylpropiolic acid chloride; 3-Cyclopropylpropynoic acid chloride; Propiolic acid, 3-cyclopropyl-, chloride; 3-Cyclopropylethynoyl chloride
EINECS	Contact for details

Quality Control

Our 2-Propynoyl Chloride, 3-Cyclopropyl- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and classification as a strong acid/organic solvent, it must be kept under an inert atmosphere (e.g., nitrogen or argon) and separated from bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.