Description

2',3',5'-Tri-o-Benzyl-4'-Thio-Arabinouridine is a key nucleoside derivative and a critical synthetic intermediate in medicinal chemistry. This compound is valued for its role in the development of novel antiviral and anticancer therapeutics, particularly as a precursor for modified nucleoside analogs. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the synthesis of advanced active pharmaceutical ingredients (APIs) and oligonucleotides.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of modified nucleoside-based antiviral and anticancer drugs.
• Oligonucleotide Synthesis: Used in the research and development of modified oligonucleotides for therapeutic and diagnostic applications.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies to explore new bioactive molecules.
• Biochemical Probe Development: Employed in the creation of probes to study enzyme mechanisms and nucleic acid interactions.
• Academic & Industrial R&D: Essential for universities and contract research organizations (CROs) focused on nucleic acid chemistry and drug discovery.

Basic Information

Product Name	2',3',5'-Tri-o-Benzyl-4'-Thio-Arabinouridine
CAS No.	267665-69-0
Molecular Formula	C30H30N2O5S
Molecular Weight	530.64 g/mol
Synonyms	4'-Thioarabinouridine, 2',3',5'-Tri-O-benzyl derivative; 1-[(2R,3S,4R,5R)-3,4-Bis(benzyloxy)-5-(benzyloxymethyl)-4-thiotetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione; 2',3',5'-Tri-O-benzyl-4'-thio-β-D-arabinofuranosyluracil; 4'-Thio-D-arabinouridine tribenzyl ether; 4'-ThioaraU tribenzyl ether
EINECS	Contact for details

Quality Control

Our 2',3',5'-Tri-o-Benzyl-4'-Thio-Arabinouridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.