Description

N4-(3-Chloro-4-Fluorophenyl)-7-(3-Morpholinopropoxy)Quinazoline-4,6-Diamine is a high-purity, advanced pharmaceutical intermediate and research chemical. This compound is a key building block in the synthesis of targeted kinase inhibitors, offering significant value for drug discovery and development programs. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of potent and selective tyrosine kinase inhibitors (TKIs).
• Oncology Research: Used in the development of targeted cancer therapies, particularly those aimed at EGFR (Epidermal Growth Factor Receptor) and related signaling pathways.
• Biochemical Research: Serves as a reference standard and a tool compound for studying enzyme kinetics, cellular signaling, and structure-activity relationships (SAR).
• Preclinical Development: Employed in the formulation and testing of new chemical entities (NCEs) during early-stage drug development.
• Custom Synthesis: Building block for the contract manufacturing of specialized APIs (Active Pharmaceutical Ingredients) and novel drug candidates.
• Academic Research: Used in university and institutional laboratories for medicinal chemistry projects and pharmacological studies.

Basic Information

Product Name	N4-(3-Chloro-4-Fluorophenyl)-7-(3-Morpholinopropoxy)Quinazoline-4,6-Diamine
CAS No.	267243-68-5
Molecular Formula	C23H25ClFN5O2
Molecular Weight	457.93 g/mol
Synonyms	7-(3-Morpholinopropoxy)-N4-(3-chloro-4-fluorophenyl)quinazoline-4,6-diamine; 267243-68-5; N-[3-Chloro-4-fluorophenyl]-7-[3-(4-morpholinyl)propoxy]-4-quinazolinamine-6-amine; EGFR Inhibitor Intermediate; Quinazoline-4,6-diamine derivative; 4,6-Diamino-7-(3-morpholinopropoxy)-N-(3-chloro-4-fluorophenyl)quinazoline
EINECS	Contact for details

Quality Control

Our N4-(3-Chloro-4-Fluorophenyl)-7-(3-Morpholinopropoxy)Quinazoline-4,6-Diamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring material produced under ICH Q7 guidelines and can provide documentation to meet regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.