Description

Canertinib is a potent and selective small-molecule inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound is a critical research tool and pharmaceutical intermediate for developing targeted cancer therapies, particularly for non-small cell lung cancer (NSCLC). It is essential for researchers in oncology, medicinal chemistry, and pharmaceutical development who require high-purity, well-characterized chemical entities for preclinical and clinical studies.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel EGFR-targeted anticancer drugs.
• Oncology Studies: Used as a biochemical tool to investigate EGFR signaling pathways, mechanisms of drug resistance, and to evaluate combination therapies in cellular and animal models.
• Medicinal Chemistry: Employed as a core scaffold or precursor for the synthesis of new analogs and derivatives with optimized pharmacokinetic and pharmacodynamic properties.
• Biochemical Assays: Utilized in high-throughput screening (HTS) and enzyme inhibition assays to identify and characterize new inhibitors or to validate assay systems.
• Academic Research: A vital reagent for universities and research institutes studying tyrosine kinase biology, cancer cell proliferation, and apoptosis.

Basic Information

Product Name	Canertinib
CAS No.	267243-28-7
Molecular Formula	C24H25ClFN5O3
Molecular Weight	485.94 g/mol
Synonyms	CI-1033; PD-183805; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide; Canertinib dihydrochloride (salt form); EGFR/ErbB-2 inhibitor; Tyrosine kinase inhibitor CI-1033
EINECS	Contact for details

Quality Control

Our Canertinib is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.