Description

4-Phosphono-L-Phenylalanine is a specialized amino acid derivative where a phosphonic acid group is incorporated into the aromatic ring of L-phenylalanine. This compound is of significant interest in medicinal chemistry and biochemistry as a non-hydrolyzable phosphotyrosine mimetic, enabling the study and inhibition of protein-tyrosine phosphatases (PTPs). It serves as a critical building block for the synthesis of peptide-based inhibitors and probes, primarily targeting researchers and developers in the pharmaceutical, biotechnology, and life science sectors.

Application

• Pharmaceutical Research: Key intermediate in the synthesis of potent and selective protein-tyrosine phosphatase (PTP) inhibitors.
• Biochemical Probes: Used to develop activity-based probes for studying phosphatase enzyme mechanisms and signaling pathways.
• Peptide Synthesis: Essential building block for incorporating phosphotyrosine analogs into peptides for structure-activity relationship (SAR) studies.
• Drug Discovery: Serves as a scaffold for developing novel therapeutics targeting diseases linked to aberrant tyrosine phosphorylation, such as cancer and diabetes.
• Enzyme Mechanism Studies: Utilized as a stable phosphonate analog to investigate enzyme kinetics and binding interactions.

Basic Information

Product Name	4-Phosphono-L-Phenylalanine
CAS No.	267236-68-0
Molecular Formula	C9H12NO6P
Molecular Weight	261.17 g/mol
Synonyms	L-4-Phosphonophenylalanine; (2S)-2-Amino-3-(4-phosphonophenyl)propanoic acid; 4-Phosphono-L-Phe; F2Pmp; 4-Phosphono-DL-phenylalanine (racemic mixture); Phosphotyrosine Mimetic; PTP Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our 4-Phosphono-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and NMR for structural confirmation. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.