Description

Ro28-2653 is a potent and selective inhibitor of matrix metalloproteinases (MMPs), specifically targeting gelatinases such as MMP-2 and MMP-9. This compound is a critical research tool for studying the role of these enzymes in physiological and pathological processes, including cancer metastasis, angiogenesis, and inflammatory diseases. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and preclinical development for oncology and other therapeutic areas.

Application

• Biomedical Research: A key biochemical tool for investigating the mechanisms of tumor invasion, metastasis, and angiogenesis in in vitro and in vivo models.
• Drug Discovery & Development: Used as a reference standard and pharmacological probe in high-throughput screening and lead optimization programs targeting MMPs.
• Enzymology Studies: Employed to study enzyme kinetics, inhibition profiles, and structure-activity relationships (SAR) of gelatinase inhibitors.
• Inflammatory Disease Research: Applied in research models for conditions like rheumatoid arthritis, atherosclerosis, and neurological disorders where MMP-2/9 activity is implicated.
• Academic & Institutional Labs: Serves as a standard reagent for graduate and post-doctoral research in molecular biology, biochemistry, and pharmacology departments.

Basic Information

Product Name	Ro28-2653
CAS No.	261956-22-3
Molecular Formula	C₂₀H₂₀N₄O₅
Molecular Weight	396.40 g/mol
Synonyms	Ro 28-2653; Ro-28-2653; 3-[[4-(4-Fluorophenoxy)benzenesulfonyl]amino]tetrahydro-2H-pyran-3-carboxylic Acid; (3S)-3-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]oxane-3-carboxylic Acid; MMP-2/MMP-9 Inhibitor; Gelatinase Inhibitor; CAS 261956-22-3
EINECS	Contact for details

Quality Control

Our Ro28-2653 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results and specifications to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.