Description

4-Methyl-3-(trifluoromethyl)benzoyl chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the combination of the benzoyl chloride functional group with a trifluoromethyl substituent, enabling the efficient introduction of both an amide linkage and fluorine-containing motifs into target molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Used in the production of fluorine-containing aromatic cores for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Serves as a monomer or cross-linking agent to introduce fluorinated aromatic units into specialty polymers, enhancing chemical and thermal resistance.
• Peptide & Protein Research: Employed as an acylating agent for modifying amino acids or for introducing specific fluorinated probes in biochemical studies.
• Dye & Pigment Manufacturing: Intermediate in the synthesis of specialized fluorinated dyes and pigments with unique color fastness and optical properties.

Basic Information

Product Name	4-Methyl-3-(trifluoromethyl)benzoyl chloride
CAS No.	261952-11-8
Molecular Formula	C9H6ClF3O
Molecular Weight	222.59 g/mol
Synonyms	3-(Trifluoromethyl)-4-methylbenzoyl chloride; 4-Methyl-3-trifluoromethylbenzoyl chloride; 3-Trifluoromethyl-p-toluoyl chloride; 4-Methyl-α,α,α-trifluoro-m-toluoyl chloride; m-Toluoyl chloride, 3-trifluoromethyl-; Benzoyl chloride, 4-methyl-3-(trifluoromethyl)-; 3-Trifluoromethyl-4-methylbenzoic acid chloride
EINECS	Contact for details

Quality Control

Our 4-Methyl-3-(trifluoromethyl)benzoyl chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and Karl Fischer titration for moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. This material is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, and strong bases. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.