Description

3-(Difluoromethylthio)Benzoyl Chloride is a high-purity, reactive organic intermediate characterized by its benzoyl chloride core functionalized with a difluoromethylthio group. This compound is valued for its role as a key building block in the synthesis of more complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and life science industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring the incorporation of a fluorinated thioether moiety for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethylthio group can improve pesticidal activity and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced materials with specific surface properties or reactivity.
• Ligand and Catalyst Preparation: Employed in organic synthesis for the preparation of specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	3-(Difluoromethylthio)Benzoyl Chloride
CAS No.	261944-16-5
Molecular Formula	C8H5ClF2OS
Molecular Weight	222.64 g/mol
Synonyms	3-[(Difluoromethyl)thio]benzoyl chloride; Benzoic acid, 3-[(difluoromethyl)thio]-, chloride; m-(Difluoromethylthio)benzoyl chloride; 3-(Difluoromethylsulfanyl)benzoyl chloride
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethylthio)Benzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizers, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.