Description

2,6-Difluoro-3-Nitrobenzoyl Chloride is a high-purity, reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine and nitro substituents, which enable precise molecular modifications essential for developing compounds with targeted properties. This intermediate is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluoro-nitrobenzoyl scaffold.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Production: Serves as a building block for advanced electronic materials, contributing to the molecular core of dyes and charge-transport molecules.
• Polymer Chemistry: Employed as a monomer or modifier to introduce aromatic fluorinated units into polymer chains, altering thermal and chemical resistance.
• Cross-Coupling Reactions: Acts as an electrophile in palladium-catalyzed reactions, such as Suzuki or Buchwald-Hartwig couplings, for constructing complex biaryl systems.
• Peptide Mimetics & Bioconjugation: Useful for acylating amines in the creation of peptide analogs or for labeling biomolecules in research settings.

Basic Information

Product Name	2,6-Difluoro-3-Nitrobenzoyl Chloride
CAS No.	260552-98-5
Molecular Formula	C7H2ClF2NO3
Molecular Weight	221.55 g/mol
Synonyms	3-Nitro-2,6-difluorobenzoyl chloride; 2,6-Difluoro-3-nitrobenzoic acid chloride; Benzoyl chloride, 2,6-difluoro-3-nitro-; 260552-98-5; 2,6-Difluoro-3-nitro-benzoylchlorid; 2,6-Difluoro-3-nitrobenzoylchloride; NSC 405124
EINECS	Contact for details

Quality Control

Every batch of 2,6-Difluoro-3-Nitrobenzoyl Chloride undergoes rigorous analytical testing to ensure it meets stringent purity and consistency standards required for sensitive synthetic applications. Our quality assurance protocols are designed to support cGMP and ISO compliant manufacturing processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.