Description

2,5-Difluorophenacyl Bromide is a high-value fluorinated organic building block, specifically a phenacyl bromide derivative. This compound is critical for introducing the reactive phenacyl bromide moiety into target molecules, enabling further synthetic elaboration. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of novel fluorinated pesticides and herbicides, where the difluoro-substitution can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated monomers or additives for advanced polymers with tailored properties.
• Chemical Biology Probes: Useful for the preparation of activity-based probes or fluorescent tags for studying biological systems.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2,5-Difluorophenacyl Bromide
CAS No.	258513-41-6
Molecular Formula	C8H5BrF2O
Molecular Weight	235.03 g/mol
Synonyms	2-Bromo-1-(2,5-difluorophenyl)ethan-1-one; 2,5-Difluorophenacyl bromide; 2',5'-Difluoro-2-bromoacetophenone; 1-(2,5-Difluorophenyl)-2-bromoethanone; α-Bromo-2,5-difluoroacetophenone; 2-Bromo-2',5'-difluoroacetophenone; (2,5-Difluorophenyl)-2-bromoethanone
EINECS	Contact for details

Quality Control

Our 2,5-Difluorophenacyl Bromide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, handling should be performed under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.