Description

Pelitinib is a potent and selective small-molecule inhibitor of the Epidermal Growth Factor Receptor (EGFR) tyrosine kinase, specifically targeting the T790M mutation associated with acquired resistance in non-small cell lung cancer (NSCLC). This high-purity compound is essential for pharmaceutical research and development, enabling critical studies in oncology and targeted therapy. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in drug discovery, preclinical testing, and the development of next-generation cancer treatments.

Application

• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in studies targeting EGFR T790M-mutant non-small cell lung cancer.
• Drug Discovery & Development: Serves as a key biochemical tool for high-throughput screening, structure-activity relationship (SAR) studies, and lead optimization programs.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and toxicity profiles of EGFR inhibitor candidates.
• Mechanistic Studies: Facilitates research into EGFR signaling pathways, resistance mechanisms, and combination therapy strategies.
• Chemical Intermediate: Can be used in the synthesis of novel derivatives or labeled analogs for advanced research applications.
• Biopharmaceutical Manufacturing: Supports process development and quality control for the production of targeted cancer therapeutics.

Basic Information

Product Name	Pelitinib
CAS No.	257933-82-7
Molecular Formula	C₂₄H₂₅ClFN₅O₃
Molecular Weight	485.94 g/mol
Synonyms	EKB-569; WAY-EKB 569; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; (E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide; EGFR Inhibitor (EKB-569)
EINECS	Contact for details

Quality Control

Our Pelitinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or desiccated conditions upon opening to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.