Description

2-Amino-2'-o-(2-Methoxyethyl)Adenosine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. Its unique structure, featuring a 2-amino substitution and a 2'-O-(2-methoxyethyl) side chain, makes it a valuable intermediate for the synthesis of novel therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral drugs, anticancer therapies, and other nucleotide-based medicines. Its precise chemical manipulation allows for the fine-tuning of pharmacokinetic properties in next-generation drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of modified oligonucleotides and nucleotide analogs for therapeutic applications.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oncology Research: Serves as a precursor in creating chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Tool: Employed in enzymatic studies and as a substrate analog to investigate nucleotide-processing pathways.
• Preclinical Development: Critical for formulation studies, pharmacokinetic (PK) profiling, and toxicology assessments of new drug entities.
• Nucleic Acid Chemistry: Utilized in solid-phase synthesis for creating research-grade oligonucleotides with enhanced nuclease resistance.

Basic Information

Product Name	2-Amino-2'-o-(2-Methoxyethyl)Adenosine
CAS No.	256224-13-2
Molecular Formula	C14H20N6O5
Molecular Weight	352.35 g/mol
Synonyms	2-Amino-2'-O-(2-methoxyethyl)adenosine; 2'-O-(2-Methoxyethyl)-2-aminoadenosine; 2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(2-methoxyethoxy)methyl]oxolan-2-yl]purine; 2-Amino-MOE-Adenosine; N2-Amino-2'-O-MOE-adenosine; 2-NH2-2'-MOE-Ado; Adenosine, 2-amino-2'-O-(2-methoxyethyl)-
EINECS	Contact for details

Quality Control

Our 2-Amino-2'-o-(2-Methoxyethyl)Adenosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development purposes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced for research use, our quality protocols align with the stringent principles of cGMP to support our clients' progression into preclinical and clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.