Description

2'-O-[2-[2-(Dimethylamino)Ethoxy]Ethyl]-5-Methyluridine is a chemically modified nucleoside derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of oligonucleotides with enhanced biological properties, such as improved stability and targeted delivery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including antisense oligonucleotides, siRNA, and other RNA-based modalities.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for introducing modified bases into synthetic RNA strands to enhance nuclease resistance and pharmacokinetic profiles.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) designed for targeted gene silencing.
• siRNA Therapeutics: Employed in the chemical modification of small interfering RNA (siRNA) to improve stability and reduce off-target effects.
• Pharmaceutical Intermediates: Serves as a high-value intermediate in the multi-step synthesis of complex nucleoside-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized in academic and industrial labs to study RNA structure, function, and RNA-protein interactions.
• Diagnostic Probe Development: Incorporated into labeled probes for diagnostic assays requiring high specificity and stability.

Basic Information

Product Name	2'-O-[2-[2-(Dimethylamino)Ethoxy]Ethyl]-5-Methyluridine
CAS No.	253145-84-5
Molecular Formula	C16H27N3O7
Molecular Weight	373.40 g/mol
Synonyms	5-Methyl-2'-O-[2-(2-dimethylaminoethoxy)ethyl]uridine; 2'-O-(2-(2-(Dimethylamino)ethoxy)ethyl)-5-methyluridine; 5-Methyl-2'-O-(2-(2-(dimethylamino)ethoxy)ethyl)uridine; DMTr-5-Me-U-CE Phosphoramidite (precursor); 2'-O-DMAEOE-5-methyluridine; N/A
EINECS	Contact for details

Quality Control

Every batch of 2'-O-[2-[2-(Dimethylamino)Ethoxy]Ethyl]-5-Methyluridine is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.