Description

Orantinib (SU6668) is a potent, small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. This compound is a critical research tool for investigating angiogenesis and tumor growth pathways, specifically targeting VEGFR, PDGFR, and FGFR. It is essential for pharmaceutical R&D, academic research, and preclinical studies in oncology and vascular biology. The product is supplied as a high-purity reference standard and active pharmaceutical ingredient (API) intermediate.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and building block in the discovery and development of novel anti-cancer therapeutics.
• Preclinical Oncology Studies: Used in in vitro and in vivo models to study the inhibition of tumor angiogenesis and growth.
• Biochemical Assay Development: Employed as a selective inhibitor to validate assays targeting VEGFR, PDGFR, and FGFR kinase activities.
• Mechanism of Action (MoA) Studies: A vital tool for elucidating signaling pathways involved in cancer progression and vascular disorders.
• Academic & Institutional Research: Supports fundamental research in cell biology, biochemistry, and molecular pharmacology related to tyrosine kinase function.
• API Intermediate Synthesis: Used as a high-purity chemical intermediate in the controlled synthesis of potential therapeutic agents.

Basic Information

Product Name	Orantinib (SU6668)
CAS No.	252916-29-3
Molecular Formula	C₂₁H₁₅N₅O₃
Molecular Weight	385.37 g/mol
Synonyms	SU6668; SU-6668; Orantinib; TSU-68; 3-[(2,4-Dimethylpyrrol-5-yl)methylidenyl]-2-indolinone; 3-[(2,4-Dimethyl-1H-pyrrol-5-yl)methylene]-1,3-dihydro-2H-indol-2-one; Receptor Tyrosine Kinase Inhibitor SU6668
EINECS	Contact for details

Quality Control

Our Orantinib (SU6668) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade and API intermediate specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.